Cyclosporine: A Review
نویسندگان
چکیده
منابع مشابه
Cyclosporine: A Review
The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has si...
متن کاملMechanisms of cyclosporine-induced renal cell apoptosis: a systematic review.
BACKGROUND/AIMS Chronic cyclosporine A (CsA) nephrotoxicity (CCN) is an important cause of chronic renal dysfunction with no effective clinical intervention. To further elucidate the mechanisms of renal cell apoptosis in CCN, all relevant in vivo studies on this subject were analyzed. METHODS We searched for in vivo studies on the mechanisms of CsA-induced renal cell apoptosis in Medline (196...
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Cyclosporine is an immunomodulatory drug used to treat an increasing spectrum of diseases in dogs. Cyclosporine is a calcineurin inhibitor, ultimately exerting its inhibitory effects on T-lymphocytes by decreasing production of cytokines, such as interleukin-2. Although, in the United States, oral cyclosporine is approved in dogs only for treatment of atopic dermatitis, there are many other ind...
متن کاملCyclosporine-A Induced Gingival Overgrowth
Background. The link between the gingival overgrowth and cyclosporine pharmacokinetical variables, especially cyclosporine doses which appear to act as stimulator of the gingival proliferative changes, presents a field of interest of large number of researches. The existence of undefined association and/or interaction between the cyclosporine and periodontal variables, could be responsible for ...
متن کاملMechanisms of renal cell apoptosis induced by cyclosporine A: a systematic review of in vitro studies.
BACKGROUND Chronic cyclosporine A (CsA) nephrotoxicity (CCN) is a major cause of chronic renal dysfunction and has no effective clinical interventions yet. OBJECTIVE To reveal the mechanisms of renal cell apoptosis in CCN, we analyzed all in vitro studies of such mechanisms. METHODS We collected all in vitro studies about the mechanisms of renal cell apoptosis induced by CsA in Medline (196...
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ژورنال
عنوان ژورنال: Journal of Transplantation
سال: 2012
ISSN: 2090-0007,2090-0015
DOI: 10.1155/2012/230386